From Nature: Bringing down the cost of cancer treatment

"In a pilot study involving 72 people, Ratain and his colleague Russell Szmulewitz, a medical oncologist at the University of Chicago, confirmed this warning by showing that a similar amount of the drug was absorbed when taken as a low dose with a low-fat breakfast as was received with a full dose when fasting. Participants could therefore take one-quarter of the normal dose and still receive the same anti-cancer effects after 12 weeks of treatment, as measured by changes in the level of prostate-specific antigen, a proxy for tumour burden."